Vascular disrupting agents (VDA) are a new class of anti-cancer drugs which obliterate all vessels in tumors and prevent nutrient supply to the tumor, thereby leading to necrosis of solid tumors.

To clarify the therapeutic significance of interrupting tumor blood flow after radiotherapy, researchers administered a powerful VDA (AC7700), on rats after irradiation.

AC770 completely destroyed the microcirculation at any time after the irradiation and inhibited tumor regrowth. In addition, the radiotherapy efficacy was significantly enhanced when combined with AC7700 - strongly suggesting that the combination was very effective in preventing cancer recurrence.

“Tumor blood flow interruption after radiotherapy strongly inhibits tumor growth”
Katsuyoshi Hori, Shozo Furumoto, Kazuo Kubota
Cancer Science Volume 99 Issue 7, Pages 1485 - 1491
DOI 10.1111/j.1349-7006.2008.00834.x
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