Particular pathways of colorectal tumor growth are closely associated with characteristic pathologic features which, in turn, determine biological behaviors such as tumor growth, invasion and recurrence.

This study compared data of 244 colorectal cancer patients who had curative surgery and examined their known genetic changes to determine the associated tumorgenesis pathways in sporadic colorectal cancer.

This novel approach of compiling genetic and molecular alterations present researchers with an opportunity to select recurrence-prone patients for strict follow-up treatments after curative operations.